CD8A and colorectal cancer: Specifically, in colorectal cancer (CRC), increased tumor infiltration by CD4+ and CD8+ T-lymphocytes (CTLs) correlates positively with overall (OS) and disease-free survival (DFS) [2].The surface presentation of antigenic peptides by the Major Histocompatibility Complex class I molecules (MHC I) is indispensable for the initiation of the CD8+ T-lymphocyte anti-tumoral immune response.