Interestingly, the effect of tapasin on both CD8+ tumor infiltration and survival is independent of the amount of membranous MHC I. However, this result may be supported by multiple studies showing that tapasin expression not only promotes MHC I cell surface expression but that it increases total antigen presentation efficacy by ensuring the loading of a wide range of stable, highly affine peptides into the MHC I complex [21–24]. This evidence concerns the gene CD8A and neoplasm.