In preparation for a risk of bias and statistical power analysis on pre-clinical animal studies on NOX2 in experimental stroke, we first conducted a systematic review63 (for search strategy see Supplementary Table 1, Supplementary Fig. 1) followed by a meta-analysis (for study characteristics see Supplementary Table 2)23, 24, 35, 36, 37, 38, 39, 40, 41, 42, 53, 64, 65. This evidence concerns the gene CYBB and Stroke.