An alternative approach to assess the cumulative effect of GWAs susceptibility in lung cancer after sub-phenotyping of COPD were submitted by Young R. et al. They have demonstrated that the risk genotypes from previously reported GWAs loci (including FAM13A and CHRNA3/5), incorporated into the algorithm with clinical variables, may estimate an overall genetic risk score20. The gene discussed is FAM13A; the disease is lung carcinoma.