No association of IREB2 rs2568494 genotypes with the results of the pulmonary function tests: FEV1 and FEV1/VC (FEV1- forced expiratory volume in 1 second; VC- vital capacity; FEV1/VC- ratio) and smoking exposure in LC cases (Table 4) was noticed. Here, IREB2 is linked to laryngotracheoesophageal cleft.