In addition, incubation with tumor cells increased cell apoptosis in all groups, however, T cells co-expressing Akt displayed less apoptosis comparing to T cells expressing CAR only, and T cells transduced with myr-Akt displayed higher apoptosis rate than T cells transduced with wtAkt, suggesting that transducing wtAkt may be more beneficial than myr-Akt. This evidence concerns the gene AKT1 and neoplasm.