Akt is necessary to induce and sustain effector functions of T cell [18, 24], comparing to their study trying to enhance the persistence of T cells by inhibition of Akt, we tried to enhance the effector functions of T cells by over-expressing Akt, these two studies take different angles to manipulate T cells to enhance the anti-tumor efficacy, and are not contradictory to each other, and it’s worth further study to determine which means is superior to the other. The gene discussed is AKT1; the disease is neoplasm.