AKT1 and neoplasm: To examine if up-regulating Akt activation could increase the activity of T cells in the presence of tumor, we transduced OT-1 cells with retroviruses encoding wild type Akt (wtAkt) or a constitutively active form of Akt (myristoylated Akt, myr-Akt), and incubated the transduced OT-1 cells with B16-OVA tumor cells.