6 observed a significant effect of APOE ε4 in general populations only – and not in pooled samples with neurological or vascular disorders; the lack of association in LBC1936 may be because of the relatively good health of the sample. Our findings do align with two individual studies of generally healthy older adults (included in the meta‐analyses) which reported no significant APOE ε4 present (vs. absent) effects [by Sveinbjornsdottir et al. 21 (n = 1725) and Jeerakathil et al. 22 (n = 368)]. There was no evidence of an independent effect of TOMM40 523 genotype here. The gene discussed is APOE; the disease is vascular disorder.