Macro-albuminuric patients with hemoglobin A1c (HbA1c )> 7.5% had a higher frequency of AT1R AC+CC genotype (33.3%) compared to micro-albuminuric patients (12%, P = 0.08) and in the presence of uncontrolled hyperglycemia the risk of macro-albuminuria increased 3.66-fold (95% CI: 0.81-16.58, P = 0.092) in carriers of AC+CC genotype. Here, AGTR1 is linked to Hyperglycemia.