Although cis-elements and other trans-acting RBPs (e.g. SRSF1 and U2AF65) appear to be involved, both directly and indirectly, Sam68 is the only RBP known to regulate AR-V7 expression and downstream transcription function that is over-expressed9, 29 and phosphorylated17 in PCa. Here, U2AF2 is linked to posterior cortical atrophy.