By knowledge-based validation, we were unable to identify up-regulation of KHDRBS1 (encoding Sam68) gene expression in CRPCa and a correlation with AR-V7 expression in primary PCa, although we did reveal up-regulation of U2AF2 gene expression in CRPCa and correlations between SRSF1 (encoding SRSF1) or U2AF2 (encoding U2AF65) and AR-V7 mRNA expression in primary PCa. The gene discussed is SRSF1; the disease is posterior cortical atrophy.