ALB and HIV infectious disease: The relationship between HAART and the liver, the site of albumin synthesis, is a balance of the beneficiary effect of immune system reconstitution versus the potential long-term toxic nature of the antiviral drugs that constitute HAART.20 Although an increase of 2.15g/L may seem clinically small, this rise in serum albumin level is a likely indicator of the overall benefit of HAART in mitigating the systemic effects of HIV infection, as described above.