The deregulation of the balance between MMPs and TIMPs is involved in the matrix degradation process in skin aging.35 Similarly, the increased production of procollagen I (Fig. 1L–O), COL3A1 (CEL), and COL1A1 (MG-H1) (Fig. 3B) can also be interpreted as an attempt to produce fresh unmodified collagen for better cell attachment or for regenerating ECM. The gene discussed is COL3A1; the disease is skin aging.