A recent study revealed that 250 mol% of collagen residues in skin are damaged by advanced glycation at 80 years of age.20 Moreover, AGE levels increased two- to fourfold in diabetes, and the biologically active AGEs and proinflammatory RAGE ligand CML are dramatically increased in sun-exposed skin.21 Given that it takes 15 years for 50% of skin collagen to turn over,22 there has been a pragmatic interest for understanding the relationship between advanced glycation and the biology of the modified extracellular matrix and its role in intrinsic skin aging and age-related skin diseases. Here, AGER is linked to diabetes mellitus.