Fibroblasts grown on CML-rich collagen undergo apoptosis23 and CML is a ligand for RAGE.24 Unlike in the present study, collagen synthesis by fibroblasts was suppressed after exposure to AGE β2 microglobulin by a mechanism that was partly RAGE dependent.25 However, the findings of very low levels of RAGE expression by fibroblasts26 do not support an important role for RAGE in the above results. This evidence concerns the gene AGER and chronic myelogenous leukemia, BCR-ABL1 positive.