Several studies have shown that long-term exposure of vascular cells to a high level of glucose causes dysfunction and promotes apoptosis.79 We have previously found that endothelial cells cultured in hyperglycemia modeling conditions (25 mM of glucose) have an impaired ability for VEGF- and serum-induced migration as well as forming capillary-like structures on Matrigel in vitro. Here, VEGFA is linked to Hyperglycemia.