Plasma PAI-1 is closely correlated with such factors as hypoxia, glucose-related signaling molecules, inflammatory cytokines, triacylglycerol, and insulin.73–75 Acosta et al.76 showed that ADSCs obtained from patients with T2DM have less fibrinolytic ability because they secrete more PAI-1 and less tissue activator of plasminogen and D-dimer. This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.