CDC6 and cancer: Also, previous research on cervical cancer cases shows that CDC6 protein was preferentially expressed in high grade lesions and in invasive squamous cell carcinoma indicating changes in up-regulation of CDC6 thereby cell proliferation and invasion.[57] The next protein CCNA2 (also known as CyclinA2) was significantly over-expressed in various cancer types, which indicated its potential roles in cancer transformation and progression [58].