As shown in Table 1, COX-1-/- 2K1C mice (preoperative SBP: 106 ± 2.4 vs. 109 ± 2.1 mmHg of WT mice, n = 6, P>0.05) developed hypertension; however, their SBP was lower, and the increase of heart mass was not to a significant extent as that of WT counterparts (Table 1). Here, PTGS1 is linked to hypertensive disorder.