NOTCH1 and Miyoshi myopathy: Finally, with regard to Notch signaling dysregulation in MM, it can be noted that “hyperdiploid” cases are associated with trisomies of different chromosomes [44] at which genes belonging to Notch pathway, such as NOTCH1 (chr.9q34.3), NOTCH3 (19p13.2–p13.1), DLL3 (19q13), DLL4 (15q14), MAML1 (5q35), and MAML2 (11q21), are located.