ATAD2 and cancer: To further explore possible underlying mechanisms for increased ATAD2 levels we utilized publicly available data from the The Cancer Genome Atlas (TCGA) consortium to investigate specific ATAD2 copy number alterations and DNA methylation status of ATAD2. In the pan cancer dataset, accessed through the TCGA copy number portal, ATAD2 was frequently amplified in 8 out of 11 total cancer types (including endometrial cancer, Supplementary Table S1), with the overall frequency of amplification of 31%.