SERPINE1 and Sepsis: Sepsis patients had also an increase of PAI-1 antigen (31.7 (21.2–41.6) vs 3.3 (1.5–5.1) ng/ml, p<0.0001) and PAI-1 activity (4.0 (1.0–9.9) vs 0.2 (0.1–0.3) ng/ml, p<0.001) compared to healthy individuals.