EGFR and neoplasm: This monoanilino-pyrimidine compound is structurally distinct from other third generation EGFR TKIs and in preclinical studies potently inhibited signaling pathways and cellular growth in both EGFR-mutant and T790M-mutant cell lines in vitro, with lower activity against wild type EGFR lines, with profound and sustained tumor regression in EGFR mutant tumor xenograft and transgenic models [87].