EGFR and non-small cell lung carcinoma: This inhibitor was well tolerated and reported a promising activity in EGFR-mutated NSCLC patients previously treated with an EGFR-TKI with a more prominent activity in T790M-positive tumors (ORR 29.2%, DCR 75.0%) than T790M-negative (ORR 11.8%, DCR 55.9%) [90].