The discovery of Epidermal Growth Factor Receptor (EGFR) mutations in NSCLC launched the era of personalized medicine in advanced Non Small Cell Lung Cancer (NSCLC), leading to a dramatic shift in the therapeutic landscape of this disease from a “one size fits all” approach to the treatment selection on molecular characteristics of tumors [1, 2]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.