Ongoing studies in resected EGFR-mutated NSCLC (NCT01405079; NCT01410214; WJOG6410L; NCI-2014–01508) will definitely provide evidence of efficacy of this strategy, as observed in other solid malignancies, such as Imatinib in GIST and Trastuzumab in HER2-positive Breast Cancer. Here, EGFR is linked to non-small cell lung carcinoma.