These results imply a possible role of endoglin in hemangioma initiation, such that, under certain conditions, overexpression of endoglin in early-stage hemangioma endothelial cells may disrupt the PP2A complex and reduce PP2A activity, in turn prompting endothelial cell growth, migration and angiogenesis by activating AKT and ERK. The gene discussed is AKT1; the disease is hemangioma.