CD133; the haematopoietic stem cell marker, CD34; the endothelial haematopoietic stem marker, p75; a cell surface marker of neural crest cells, Sox-10; the neural crest stem cell marker, Oct-4; STAT-3; the human embryonic stem cell markers and vimentin; the mesenchymal stem cell marker, were all detected in tumor tissues of the transgenic animals (Fig. 2B, 2C, 2D, 2E, 2F, 2G, 2H). Here, STAT3 is linked to neoplasm.