Other transcription factors have similarly been involved in promoting miR-7 expression via directly interacting with the promoter regions of miR-7 genes including homeobox D10 (HOXD10) via the MIR7-1 promoter region in breast cancer [2] and Hepatocyte Nuclear Factor 4 alpha (HNF4α) via the MIR7-2 promoter in hepatocellular carcinoma (HCC). This evidence concerns the gene HNF4A and hepatocellular carcinoma.