For example, Proteasome Activator Subunit 3 (PA28γ) which promotes cell cycle progression has been shown to be directly targeted by miR-7 in the hamster ovarian cell line CHO, non-small cell lung cancer (NSCLC) and breast cancer via its 3′-UTR [44,45,46]. The gene discussed is PSME3; the disease is non-small cell lung carcinoma.