PIK3CD and cancer: Additionally, miR-7 affects the activity of multiple oncogenic molecules in the EGFR signaling cascade such as Akt and ERK1/2 [4,53], V-Raf-1 murine leukemia viral oncogene homolog (RAF1) [4,10,43,53], P21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) [2,51], activated CDC42 kinase 1 (ACK1) [51], phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (PIK3CD), mammalian target of rapamycin (mTOR), phosphoprotein 70 ribosomal protein S6 kinase (p70S6K) [54] and PI3K [53] across several cancer types, demonstrating broad regulatory control over this signaling network.