PTPN1 and obesity due to melanocortin 4 receptor deficiency: In this section of the review, we attempt to discuss the anti-diabetic targets of seaweed bioactive compounds including inhibition of enzymes involved in maintenance of glucose homeostasis such as α-amylase, α-glucosidase, aldose reductase and protein tyrosine phosphatase 1B (PTP1B), inhibition of incretin hormones activities, promotion of glucose uptake by cells, anti-obesity, as well as anti-inflammation and cytoprotection of β-cells.