CCAT1-L, as a novel CRC-specific lncRNA, was shown to be abundantly transcribed from a locus 515 kb upstream of MYC, and CCAT1-L could influence MYC transcriptional regulation and promote long-range chromatin looping in which CCAT1-L may interact with CTCF and modulate chromatin conformation [149]. This evidence concerns the gene CTCF and colorectal carcinoma.