The investigation of the association between HOTAIR tag SNPs and the risk of CRC showed that patients with the rs7958904 CC genotype had a decreased risk of CRC and the rs7958904 C allele was associated with the inhibition of cell proliferation compared with the rs7958904 G allele, indicating that genetic variants of HOTAIR play important roles in CRC [137]. Here, HOTAIR is linked to colorectal carcinoma.