IGF1R and malignant colon neoplasm: The main findings also included the following: (1) Our work presented evidence to demonstrate that curcumol regulated the expression of IGF-1R in colon cancer cells; (2) Curcumol induced LoVo cell apoptosis via an IGF-1R/p38 MAPK signal pathway; (3) Curcumol could suppress the growth of human colorectal cancer xenografts in vivo.