ASCL2 and colorectal carcinoma: Blockade of Ascl2 expression in HT-29 and LS174T cells results in tumor growth arrest via miRNA-302b-mediated inhibition of CRC progenitor cells and induces miR-200 family expression, further promoting epithelial-mesenchymal transition (EMT)-mesenchymal-epithelial transition (MET) plasticity via a transcriptional mechanism [10, 11].