LDLR and familial hyperaldosteronism: Since constitutive LDLR transgene expression for treating FH has not yet achieved a cure17, 18 and may even be cytotoxic19, 20 we elected to use the plasmid pEHZ-LDLR-LDLR to impart physiological responsiveness by 10 kb of up-stream genomic control sequences8, 21, 22.