The mechanisms that can activate CAFs in the stroma are still not clearly understood but it is believed that tumor released factors such as tumor growth factor beta (TGF-β), platelet derived growth factor α/β (PDGFA, PDGFB), fibroblast growth factor (FGF) and interleukin-6 (IL-6) play major roles in trans-differentiation and activation of CAFs [3–6]. The gene discussed is IL6; the disease is neoplasm.