The third tumor (TCGA-G4-6304, Table 2 and Fig. 2, lower panel) had S.ind below but close to the cutoff of 0.395 and relatively high T.sns and S. This tumor could be a boundary case in which, for example, MMR deficiency might have arisen only late in tumor development, resulting in relatively few simple-repeat-length changes and relatively few SNSs. Here, MRC1 is linked to hyperinsulinemic hypoglycemia, familial, 4.