Pharmacological mTOR inhibition by rapamycin has been shown to improve cardiac function in PO LVH, after myocardial infarct, in a LEOPARD syndrome model and after kidney transplantation (Gao et al. 2006; Kuzman et al. 2007; Shioi et al. 2003; Marin et al. 2011). This evidence concerns the gene MTOR and Noonan syndrome with multiple lentigines.