In particular, it has been shown that the enforced expression of miR-17 in primary unmutated IGHV CLL cells reduces the expression of the tumor suppressor genes E2F5, TP53INP1, TRIM8 and ZBTB4. Among these genes, ZBTB4 and TP53INP1 are involved in apoptosis regulation through CDKN1A and TP53 [86, 87], E2F5 is involved in the G1 arrest [88], and TRIM8, is involved in the degradation of SOCS1, a well-known regulator of the response to CpG [89]. Here, E2F5 is linked to B-cell chronic lymphocytic leukemia.