In the same study [22], we also demonstrated that the stable and sustained up-regulation of miRNAs belonging to the miR-17-92 cluster in unmutated IGHV CLL by CpG is preceded by induction of MYC, thus providing evidence of an associative interaction between MYC and miR-17-92 cluster also in CLL cells. Here, MYC is linked to B-cell chronic lymphocytic leukemia.