The 30 proteins decreased only in metastatic tumors (Table 4) exhibit top canonical pathways associated with cell junction signaling and remodeling of epithelial adherens junctions based on gelsolin, integrin beta-1, tubulin beta-4B, tubulin beta-3, tubulin alpha-4a, and tubulin beta-2A. The gene discussed is ITGB1; the disease is metastatic neoplasm.