PNPLA8 and parasitic infectious disease: Sharma et al. described that deficiency of iPLA2-γ (Ca++ independent PLA2 isoform-γ), which is involved in AA membrane release, aggravated infection and decreased survival, while Mukherjee et al. described that COX-1-/- mice showed higher parasitemia than wild type infected mice, but no difference in survival was noted [27].