Recently, it was shown that high PD-L1 expression was associated with the presence of epidermal growth factor receptor (EGFR) mutation in advanced lung adenocarcinoma and PD-L1 overexpression was considered as a poor prognostic indicator in EGFR wild-type patients but not in EGFR mutant patients [84]. The gene discussed is EGFR; the disease is lung adenocarcinoma.