While HIF-1α is known to regulate proteolytic enzymes such as uPAR, cathepsins, MMP-1, MMP-2, MMP-9 in many cancer types [22, 26], HIF-2α has directly been involved in membrane bound MT1-MMP in von Hippel-Lindau renal cell carcinoma [27]. This evidence concerns the gene EPAS1 and cancer.