It has recently been shown that ANO1/TMEM16A is amplified or overexpressed in several human cancers such as gastrointestinal stromal tumors (GIST), prostate cancer, head and neck squamous cell carcinoma (HNSCC), breast cancer and colorectal cancer cells [27, 30–33]. The gene discussed is ANO1; the disease is head and neck squamous cell carcinoma.