The observed difference in ANO1 expression between the adenocarcinoma and squamous cell carcinoma likely highlights the biological differences between these two subtypes, it also suggests different tumor suppressor genes that may be related to the genesis of each histologic type [48, 49].The mechanism underlying ANO1 in proliferation and migration of lung cancer cells is not investigated in this study. The gene discussed is ANO1; the disease is adenocarcinoma.