To gain further insight into the state of DIS3 mutations longitudinally, we analyzed 19 patients for whom BM specimens were collected at two different timepoints: in particular, fourteen MM and two pPCL cases collected both at onset and at relapse; two MM patients at onset and at leukemic transformation, and one patient at early and relapsed leukemic phase of MM (Figure 2, Supplementary Table S3). This evidence concerns the gene DIS3 and Miyoshi myopathy.