DIS3 and plasma cell myeloma: Furthermore, looking at DIS3 mutations in longitudinally analyzed patients (i.e. sampled at diagnosis and relapse), we observed a similar scenario to that described by Bolli et al. [3] for other known driver myeloma genes, i.e. the occurrence of clonal variants at both timepoints or the acquisition/clonal expansion of variants at the later timepoint, consistently with an expected positive selection for the subclones harboring them.