Submap analysis [39] of four publicly available datasets of IL21-treated vs. untreated (i) human CLL cells (GSE50572) [24] (ii) human Sezary T cells (GSE8685) [41] (iii) murine naïve CD8+ T cells (GSE2059) [42] and (iv) murine pre-activated CD4+ T cells (GSE19198) [43] showed regulation of the same or orthologous genes coherent with those identified in our dataset (S1 Fig). The gene discussed is CD4; the disease is B-cell chronic lymphocytic leukemia.