CALR and neoplasm: The cells undergoing immunogenic death are able to release or translocate specific signals such as calreticulin (CRT), heat shock proteins (HSPs), high mobility group box 1 protein (HMGB1), ATP [24,25,26,27,28], etc. Some of the signals are operated on a series of receptors controlled by dendritic cells which present the tumor antigens to T-lymphocytes, constituting a pathway to activate the therapeutic immune responses [29].