Within the LHCGR window, SNPs in the 5’ and intron 1 regions of the LHCGR gene, surrounding the PCOS risk SNP rs13405728, were associated with methylation level of three CpG residues clustered in the STON1-GTF2A1L gene (S5 Table and Fig 3). The gene discussed is GTF2A1L; the disease is polycystic ovary syndrome.