A lower fraction of FOXP3+ T cells expressed the nTreg marker Helios in LPL (Fig 3c) than PBMC (Fig 3d) in all cohorts (p<0.0001), but the percent of FOXP3+ T cells expressing Helios was no different in the LPL of patients with or without IBD, regardless of inflammation (Fig 3c). The gene discussed is IKZF2; the disease is inflammatory bowel disease.