Further, NSCLC cell-lines over-expressing the VEGF-C/VEGFR3 axis showed increased migration, and, when introduced into xenograft models, more frequently formed lung metastases, compared to NSCLC cell-lines where VEGF-C/VEGFR3 signaling had been abrogated [11]. The gene discussed is VEGFC; the disease is non-small cell lung carcinoma.