Subgroup analyses reporting on VEGF-C and survival in 4 studies of adenocarinomas (n = 317) and 5 studies of stage I NSCLC (n = 542) revealed HRs of 1.45 (95% CI: 1.04–2.03) and 1.56 (95% CI: 1.09–2.24), respectively (Fig 2A). This evidence concerns the gene VEGFC and non-small cell lung carcinoma.