This current meta-analysis correlates VEGF-C, VEGFR3 and high levels of LVD with nodal metastasis in NSCLC patients and identifies high VEGF-C (HR 1.57 95% CI: 1.34–1.84) and high levels of LVD (HR 1.84 95% CI: 1.18–2.87) as significant prognostic markers of poor survival. The gene discussed is VEGFC; the disease is non-small cell lung carcinoma.