The results of this meta-analysis indicate that VEGF-C is a prognostic factor for lymph node metastasis (HR 1.66 95% CI: 1.28–2.15) and survival (HR 1.57 95% CI: 1.34–1.84) in NSCLC patients, and further, that high expression of VEGFR3 is a prognostic factor for lymph node metastasis (HR 1.71 95% CI: 1.34–2.18). The gene discussed is FLT4; the disease is metastatic malignant neoplasm in the lymph nodes.