In recent years it has become clear that invadopodia have an important role in the invasion of glioma [30], and several proteins which are involved in the formation of invadopodia in glioma cells have been further explored as potential therapeutic targets such as synaptojanin [42], diaphanous-related formin 1 [43], the small GTPase RhoG [44] and CRN2 [45]. This evidence concerns the gene RHOG and glioma.