As shown in Fig. 7A,B, the effect of siHCRP-1 on phospho-ERK and MMP-2 up-regulation were significantly blocked in EGFR-depleted RCC cell lines, and the ability to migrate or invade was also decreased in RCC cells transfected with siRNA for EGFR (Fig. 8C,D). The gene discussed is MMP2; the disease is renal cell carcinoma.