4). Moreover, UCP-2 expression has been associated with paclitaxel resistance of p53 wildtype lung cancer, CPT-11 resistance of colon cancer, and gemcitabine resistance of pancreatic adenocarcinoma, non-small cell lung adenocarcinoma, or bladder carcinoma. Accordingly, experimental targeting of UCPs has been demonstrated to sensitize tumor cells to chemotherapy in vitro. (for review see Ref. 4). The gene discussed is TP53; the disease is colonic neoplasm.