Although some tumor specimens close to necrotic tumor areas (i.e., from presumed hypoxic regions, TN in Fig. 6B) showed extremely high UCP-3 protein abundance while peripheral tumor (TP in Fig. 6B) exhibited very low expression, the average UCP-3 abundance of TN specimens was not significantly different from that of the tumor samples of non-defined origin (data not shown). The gene discussed is UCP3; the disease is neoplasm.