The TCGA data suggest co-occurrence of high abundant UCP-2 and UCP3 mRNA in the ccRCC specimens (data not shown) as well as shorter survival of ccRCC patients with high UCP-2 or UCP-3 mRNA abundance in the tumors as compared to the patients with “middle-rate” UCP expressions (Suppl. The gene discussed is UCP1; the disease is nonpapillary renal cell carcinoma.