Median Levels of sFlt-1, 8-epi-PGF2α and sFlt-1/PLGF were significantly elevated among study participants with PE co-existing with IUFD, placental abruptio, placental previa, HELLP syndrome and IUGR compared to PE without adverse outcome (p = 0.041, p = 0.005, p = 0.0002). The gene discussed is PGF; the disease is fetal growth restriction.