The most accurate predictor of PAPPA for preeclampsia was PAPPA < 0.4 MoM; LR+ 2.17 (1.48, 3.17), LR- 0.91 (0.85, 0.97), for SGA was PAPPA < 1st centile; LR+ 3.59 (2.77, 4.40), LR- 0.98 (0.97, 0.98). This evidence concerns the gene PAPPA and preeclampsia.