The most accurate predictor of PAPPA for preeclampsia was PAPP-A < 5th centile, with LR + 2.10 (1.57, 2.81), LR- 0.95 (0.93, 0.98); for SGA was PAPP-A < 1st centile; LR+ 3.50 (2.53, 4.82), LR- 0.98 (0.97, 0.99). The gene discussed is PAPPA; the disease is preeclampsia.