A yeast two-hybrid screen identified a number of small-molecule “disinactivators” that most likely interact with sites on the KVβ1 N-terminus or its receptor site on KV1.1 and prevent it binding and inhibiting KV1.1 channels.39 It is suggested that drugs based on these disinactivators may ultimately be useful for preventing inactivation of KV1.1 channels in the brain and thus reducing neuronal hyperexcitability in diseases such as epilepsy. The gene discussed is KCNA1; the disease is epilepsy.