The aim of this study was to investigate the relationship between CHCHD3P1-HSP90AB7P, GRID1, HSPA12A, PRLHR, SBF2, POLD3, and C11orf93-C11orf92 genes and susceptibility to gastric and colorectal cancers in the Chinese Han population. Here, POU2AF3 is linked to colorectal cancer.