While the lowest dose (10 μg) of ENO1 did not modulate the severity of arthritis, the highest dose of ENO1 (100 μg) significantly reduced the severity of arthritis both for global score (p<0.05) (Fig 1A), articular score (p<0.05), (Fig 1B) and weight variation (p<0.001) (Fig 1C) while there was only a trend in the reduction of ankle thickness (p = 0.09) (Fig 1D). This evidence concerns the gene ENO1 and Arthritis.