However, given that mutations in exon 2 are associated with DFNB3 deafness in humans, it strongly suggests that isoform 1 also has a critical role in the auditory system (Nal et al., 2007; Cengiz et al., 2010; Bashir et al., 2012; Fattahi et al., 2012). The gene discussed is MYO15A; the disease is deafness.