The mTORC2 is a critical regulator of glycolytic metabolism in cancer, mainly via AKT activation.46 SREBP-1 cleavage by AKT-dependent and -independent mechanisms suggest that mTORC2 is also a key controller of lipid metabolism in tumors such as glioblastoma.19 We demonstrate that DGKζ silencing regulates SREBP-1 levels while promoting AKT phosphorylation, showing additional controls on SREBP-1. This evidence concerns the gene DGKZ and cancer.