ANXA5 and acute lymphoblastic leukemia: Most of the untreated ALL cells were non-apoptotic (Annexin-V negative/PI negative), while upon treatment with SB225002 a marked increase in the number of early (Annexin-V positive/PI negative) and late apoptotic (Annexin-V positive/PI positive) cells was observed in both B- and T-ALL cells (Fig 1D).