NFE2L2 and neoplasm: To evaluate the effect of AIM-mediated NRF2 induction on tumor cell growth and survival, we first characterized the basal level of NRF2 activity in a panel of tumor cell lines to identify those that had a wild-type KEAP1-NRF2 axis (ie, low basal NRF2 levels), and those that had a dysfunctional KEAP1-NRF2 axis (ie., high basal NRF2 levels).