In this study, we found that RTA 405-mediated inhibition of tumor cell growth (IC50 and GI50 values) did not correlate with basal NRF2 activity or with the ability of RTA 405 to increase NRF2 activity (Fig 7), consistent with many studies that have shown that RTA 405 modulates the activity of other proteins that directly influence the growth and survival of tumor cells. This evidence concerns the gene NFE2L2 and neoplasm.